Enjoy all the anti-aging benefits while sleeping in a natural state of calm, with the new anti-aging superstar ingredient, Spermidine!
Human cells gradually age, and some protein structures will turn dysfunctional and become garbage. If it is not cleaned up in time, it will accelerate aging and bring about a series of aging diseases.
In 1963, Christian René de Duve, a Nobel Prize-winning Belgian cytologist and biochemist, first discovered autophagy, a process in which cells break down their own structures through the mechanism of lysosomes and then undergo self-regeneration. This process not only provides energy for organism cells but also supplies materials for cell renewal and regeneration. It is also helpful in destroying bacteria and viruses during infections. Additionally, cells utilize autophagy to remove damaged proteins and organelles, combating the negative effects of aging on the organism.
Since 1990, Yoshinori Ōsumi, a Japanese scientist, has conducted extensive research on autophagy, and in recent years, has made groundbreaking discoveries about its broader role in biology. These include organellar remodeling, protein and organelle quality control, prevention of genotoxic stress, tumor suppression, pathogen elimination, regulation of immunity and inflammation, maternal DNA inheritance, metabolism, and cellular survival. As a result, not only does autophagy reduce the risk of infection but also helps slow down aging and extend lifespan.
Yoshinori Ōsumi was subsequently awarded the Nobel Prize in Physiology or Medicine in 2016 for elucidating the mechanism of autophagy.
Spermidine has been clinically proven to enhance autophagy that naturally slows with age, thereby helping to maintain gene stability, and regulate various cellular processes, including DNA stability, cell growth, cell differentiation, apoptosis, and more.
In fact, Spermidine has been found to be even more effective as an anti-aging supplement, especially in terms of skin, hair and nails, than NMN due to its autophagy mechanism and its ability in improving multiple aging pathways (six out of nine) compared to NMN, which relies on boosting NAD levels through an enzymatic process.
Agent Nateur calm(beauty) is a non-drowsy, melatonin-free liquid formula filled with potent concentrations of the highest quality, clinically proven vitamins, minerals, and amino acids, including pure Spermidine, Taurine, Organic Tart Cherry, Glycine, GABA, L-Theanine, Vitamin D3, Pantothenic Acid (Vitamin B5), Vitamin B6, 5-HTP, Tryptophan, and Magnesium Citrate, to reverse damages at the cellular level and cultivate ageless beauty.
Individually packaged in Organic Tart Cherry-flavored liquid sachets for optimal absorption before sleep, calm(beauty) is brimming with the pure form of anti-aging Spermidine, a natural polyamine compound found in humans, that has been shown to promote cellular autophagy, a natural process that helps to remove damaged cellular components and promotes the regeneration of healthy cells, while healing the gut lining, reducing internal inflammation, protecting cardiovascular and neurological health, reducing oxidative damage, as well as improving metabolic function and longevity.
By facilitating a stable internal environment where skin has the potential to naturally repair itself and inflammation reduced, Spermidine also helps to reduce signs of aging, including fine lines, wrinkles, premature aging, and scars, as well as provide relief for various skin conditions, such as acne, eczema, rosacea, and psoriasis.
Moreover, it has been shown to support hair growth by moving hair follicles into the growth phase, protecting hair follicles from oxidative stress and strengthening follicular integrity, thereby promoting hair growth and hair thickness. Moreover, thanks to its autophagy-inducing properties that contribute to recycling and restoring pigment-producing cells, it may even have the potential of reversing gray hair!
In fact, research shows that Spermidine improves multiple aging pathways (six out of nine) and is thus better for skin, hair, and nails in terms of anti-aging benefits than NMN.
calm(beauty) is further enriched with Taurine, an amino acid that has been associated with cardiovascular, neurological, eye, and skin benefits. For the skin, it has been found to exhibit antioxidant effects, whilst promoting moisture retention and collagen synthesis, which are all essential for healthy, younger looking skin. It has also been shown to have anti-inflammatory properties, which can be beneficial for various skin conditions, including acne, eczema, rosacea and psoriasis.
In addition, Taurine also activates GABA(A) receptors in the brain region that regulates sleep, calms anxiety and lessen reactivity to stress, and is involved in the creation of melatonin in the pineal gland, all of which help with the repair of cells and promote the regeneration of healthy cells, as cell repair and regeneration happen when we sleep.
To maximise the process of cell repair and regeneration during sleep, the formula is further filled with Organic Tart Cherry, a natural source of melatonin, as well as Glycine, GABA, L-Theanine, Pantothenic Acid (Vitamin B5), Vitamin B6, Vitamin D, 5-HTP, Tryptophan, and Magnesium Citrate to improve sleep quality, help to fall asleep faster and stay asleep longer, reduce symptoms of restless legs syndrome, ease muscles and tensions, calm anxiety, and regulate the body’s stress response.
Cellular Rejuvenation Spermidine has been shown to promote cellular autophagy, a natural process that helps to remove damaged cellular components, promote the regeneration of healthy cells, as well as improve metabolic function and longevity. This cellular rejuvenation process have significant anti-aging effects for the body, including skin and hair.
Improves Signs of Skin Aging Such As Firmness, Texture, Fine Lines & Wrinkles By reducing the accumulation of damaged proteins, improving cellular function, reducing inflammation, creating a stable internal environment where skin has the potential to naturally repair itself, Spermidine helps to mitigate signs of aging, including fine lines, wrinkles, sagging skin, loss of elasticity, premature aging, and scars.
Improved Skin Barrier Function & Moisture Retention Spermidine has been reported to enhance the skin's barrier function and improve its ability in retaining moisture and defending against external irritants, pollutants, and pathogens. By improving the skin's hydration levels, it may also help prevent dryness and maintain a supple and plump appearance.
Anti-inflammatory Effects, Improves Eczema, Atopic Dermatitis, Rosacea and Sensitive Skin Spermidine has been found to have anti-inflammatory properties, which can help to modulate the immune response, reduce chronic inflammation, help calm and soothe irritated skin, reduce redness and promote a more even complexion, thereby improving various skin conditions, such as acne, eczema, rosacea, and psoriasis.
Hair Growth and Thickness, Potential Reversal of Grey Hair Spermidine acts on multiple fronts to stimulate hair growth. By inducing autophagy, it helps to regulate the hair cycle, upregulate the expression of epithelial stem cell-associated keratins, protect hair follicles from oxidative stress and strengthen follicular integrity, while directly effecting on hair follicles during the anagen phase, and promoting hair shaft elongation and overall hair growth and hair thickness. In addition, by neutralizing oxidative stress, promoting melanin synthesis and preventing melanocyte depletion in the scalp, spermidine may hold potential in reversing the graying process and restoring hair pigmentation.
Cardiovascular Protection Spermidine has been associated with cardiovascular health benefits. It may help reduce oxidative stress, inflammation, and improve heart function. Studies have suggested that spermidine intake may lower the risk of cardiovascular diseases.
Neurological Protection Spermidine has shown neuroprotective properties in preclinical studies. It may help protect against age-related cognitive decline and neurodegenerative diseases by promoting brain health and reducing the accumulation of toxic proteins. In 2013, German and Austrian scientists collaborated to find that Spermidine can prevent the onset of Alzheimer’s disease.
Antioxidant Activity Spermidine exhibits antioxidant properties, which help to neutralize harmful free radicals and reduce oxidative stress, thereby contributing to overall cellular health and slowing the aging process for the body, including skin and hair.
Antioxidant Activity Taurine exhibits antioxidant properties, which can help neutralize harmful free radicals and reduce oxidative stress in the skin. By doing so, it may protect the skin from damage caused by environmental factors, such as UV radiation and pollution.
Collagen Synthesis Taurine has been suggested to promote collagen production, thereby reducing signs of aging, such as fine lines, wrinkles, sagging skin and loss of elasticity.
Moisture Retention Taurine can help improve the skin's ability to retain moisture, and prevent dryness.
Anti-inflammatory Effects, Improves Eczema, Atopic Dermatitis, Rosacea and Sensitive Skin Taurine has been shown to have anti-inflammatory properties. It may help reduce inflammation in the skin, which can be beneficial for various skin conditions, including acne, eczema, and dermatitis.
Cardiovascular Health Taurine can help reduce blood pressure, improve blood lipid profiles, and support healthy heart function.
Neurological Effects Taurine helps to protect against oxidative stress, regulate neurotransmitters, and support brain development and function. Taurine supplementation has been studied for its potential benefits in conditions such as epilepsy and Alzheimer's disease.
Eye Health Taurine is present in high concentrations in the retina, and it plays a crucial role in maintaining retinal health. It has been associated with the protection of retinal cells from oxidative damage and the prevention of age-related macular degeneration.
Sleep Promotion Taurine activates GABA(A) receptors in the brain region that regulates sleep, calms anxiety and lessen reactivity to stress, and is involved in the creation of melatonin in the pineal gland.
A box contains 15ml x 24 packets, to be taken at night before sleep.
Formulated specifically for the following concerns:
Cell aging
Fine lines & wrinkles
Aging skin
Sagging skin, loss of elasticity
Skin inflammations, including acne, eczema, rosacea and psoriasis
Hair loss
Gray hair
Brittle nails
Stress
Poor and restless sleep
Insomnia
Cardiovascular health
Neurological health
Eye health
Each 15ml packet contains:
Calories - 10
Total Carbohydrate - 3g
Vitamin D3 (as Cholecalciferol from Lichen) - 20mcg
Take 1 packet daily 30 minutes - 1 hour before sleep. Can be taken straight from the packet, or added to cold water or sparkling water.
Spermidine - the spermidine in calm(beauty) is a pure form derived from amino acids, which is more superior and pure compared to those derived from wheat germ or a synthetic blend of spermidine with wheat germ. For details, please refer to the "Description" section.
Taurine - for details, please refer to the "Description" section.
Organic Tart Cherry Juice Concentrate - a source of natural melatonin (as opposed to synthetic melatonin supplements), organic tart cherry is also rich in vibrant red and purple anthocyanins, which are antioxidants that work to support healthy skin and reduce inflammation.
Glycine - serves as both a key component of collagen and supports the production of serotonin, the “feel good” hormone. It has been clinically studied to improve mood and memory, enhance sleep by promoting REM, support healthy detoxification, and a healthy heart and brain.
L-Theanine - a non-protein amino acid sourced from green tea and well known for supporting states of relaxation and calm without causing drowsiness. A neuroprotective and cognitive-enhancing agent, it works together with glycine in the process of modulating the central nervous system to take the body out of a state of stress and promote quantity and quality of sleep.
GABA - the main inhibitory neurotransmitter in the human brain known to calm and soothe the central nervous system, it works to dial down the noise in the central nervous system, supporting better quality sleep and a reduction of stress.
5-HTP - derived from Griffonia seed, 5-HTP is a precursor to serotonin, the neurotransmitter responsible for happiness and indirectly involved in producing melatonin, the hormone critical for sleep.
Magnesium Citrate - helps reduce muscle tension, promotes relaxation and can contribute to better sleep quality by helping to regulate GABA production and the central nervous system. Linked to HPA axis regulation, it helps to modulate stress hormones and can contribute to the reduction of stress and anxious feelings.
Vitamin D3 - sourced from lichen, it is a necessary vitamin in the support of melatonin production, and aids in maintaining the body’s natural circadian rhythm for better quality and longer sleep.
Vitamin B6 - supports the synthesis of melatonin, GABA, and serotonin, and plays heavily in the hormonal regulation of sleep, mood levels, and relaxation. It also contributes to normal energy-yielding metabolism and to normal functioning of the nervous system.
Pantothenic Acid (Vitamin B5) - a vitamin involved in the synthesis of acetylcholine, a neurotransmitter that plays a role in the regulation of sleep wake cycle and is involved in REM sleep. It also contributes to normal mental performance and the reduction of tiredness and fatigue.
L-Tryptophan - an essential amino acid that serves as a building block for proteins in the body, it also plays a crucial role in the synthesis of various important molecules, such as serotonin and melatonin, and thus can help in regulating mood and mental health, improving sleep quality, reducing stress and anxiety, and support cognitive functions, including memory, learning, and attention.