B12 CALM SERUM

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  • ■ Skin is prone to redness and sensitivity
    ■ Has eczema, rosacea issues
    ■ Skin easily feels stinging/prickling sensations due to damaged barrier
    ■ Skin is easily irritated
    ■ Needs highly soothing and reparative products after aesthetic procedures



    Twelve Beauty founder Dr. Pedro Catalá: "For years, my mission has not changed: soothing and improving sensitive skin remains the guiding principle behind every formula I create. B12 Calm Serum is my dedication to those with sensitive skin, eczema, and rosacea. There is no randomness in any ingredient of this serum; each component is meticulously chosen with a clear purpose – to support and strengthen the delicate structure of compromised skin."

    The distress suffered by sensitive skin, such as persistent redness, recurrent inflammation, discomfort triggered by environmental irritants——these are problems that require targeted solutions.

    From the first use, B12 Calm Serum, with its exceptional skin affinity, instantly melts into the skin to soothe redness and signs of sensitivity, bringing immense comfort without any burden or irritation.

    With continuous use, the anti-inflammatory and reparative formula effectively strengthens the skin's protective barrier, enhances the skin's own ability in resisting external irritants, while maintaining the integrity, strength, and elasticity of the skin structure, fundamentally improving persistent redness and inflammatory issues, and allowing the skin to restore its rightful balance, stability, and healthy glow.






    Cyanocobalamin (Vitamin B12)
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    The source of the pink color in B12 Calm Serum. Effectively soothes sensitivity and redness, reduces inflammation, strengthens the skin's defense, enhances the skin's repair capabilities, maintains barrier health, and promotes healthy skin cell growth to improve overall skin texture.


    Alteromonas Ferment Extract
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    A precious active ingredient from the deep sea, it provides powerful hydration, significantly increasing the skin's moisture content, and forms a water-locking barrier to ensure plump and hydrated skin. Additionally, it has significant anti-inflammatory, soothing, and calming effects to help reduce redness and alleviate signs of sensitivity, while strengthening the skin barrier function, defending against environmental stressors, and promoting cell repair and regeneration.


    Micrococcus Lysate
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    An enzyme derived from Micrococcus, it effectively helps skin cells recover from damage caused by UV radiation and environmental stress, thereby strengthening the skin's natural repair mechanisms, enhancing its overall health and resilience, while reducing visible signs of skin damage and providing preventive protection for the skin.


    Panthenol (Pro-Vitamin B5)
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    A recognized powerful moisturizing and soothing ingredient. It penetrates deep into the skin, helping to repair and strengthen the skin barrier function, thereby significantly enhancing the skin's water retention capacity, and reducing moisture loss. Additionally, it possesses excellent anti-inflammatory and reparative properties to help soothe irritated skin, accelerate wound healing, and reduce redness and discomfort.


    10 Amino Acids
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    Crucial for the synthesis of keratin, collagen, and elastic fibers, which helps to maintain the skin's structural integrity, strength, and elasticity, while providing antioxidant benefits. Moreoever, they are key components of the skin's Natural Moisturizing Factor (NMF) that are vital for maintaining moisture, strengthening the skin's natural barrier function, and promoting a smooth, soft skin texture.


    Lemon Peel Powder | Lime Peel Powder
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    Rich in Vitamin C, citric acid, flavonoids, and other active ingredients and powerful antioxidants, as well as excellent antioxidant, anti-inflammatory, and antibacterial properties, they can combat free radicals, calm and soothe redness and sensitivity. Additionally, they help detoxify the skin to enhance skin health and vitality.


    Sodium PCA | PCA
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    Excellent hydrating and water-locking ingredients that help to significantly reduce transepidermal water loss and strengthening the skin's natural barrier, while providing deep and long-lasting hydration to the skin.


    Sodium Hyaluronate
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    Hydrates and resolves dryness, while forming a highly effective film on the skin's surface for long-lasting water retention.


    * For detailed explanation of the ingredients, refer to the "Key Ingredients" section.








    ✓ Reduces persistent redness
    ✓ Soothes sensitivity
    ✓ Calms inflammatory issues such as eczema and rosacea
    ✓ Antibacterial
    ✓ Fights free radicals that exacerbate inflammations
    ✓ Strengthens skin's lipid barrier
    ✓ Accelerates skin repair after surgery or aesthetic treatments
    ✓ Promotes skin cell repair and regeneration
    ✓ Increases skin moisture content






  • Every morning and night after using Ultra Revitalising Elixir, take an appropriate amount and smooth onto the face and neck, then lightly press to enhance absorption. Follow with Essential Bio-Technological Moisturiser or Nutritive Repair Emulsion


    Suitable for all skin types, including oily, acne-prone, sensitive, and inflamed skin.







    1. Cyanocobalamin (Vitamin B12)
      Effectively soothes sensitive redness, reduces inflammation, strengthens the skin's defense, enhances skin's repair capabilities, and promotes healthy skin cell growth to improve overall skin texture. Furthermore, it is crucial for maintaining the integrity of the skin barrier, thus helping to reduce moisture loss, enhance hydration, and maintain overall skin health and vitality.

    2. Alteromonas Ferment Extract
      A precious active ingredient derived from the deep sea, it provides powerful hydration, significantly increasing the skin's moisture content, and forms a water-locking barrier to ensure plump and hydrated skin. Additionally, it has significant anti-inflammatory, soothing, and calming effects to help reduce redness and alleviate signs of sensitivity, while strengthening the skin barrier function, defending against environmental stressors, and promoting cell repair and regeneration.

    3. Micrococcus Lysate
      An enzyme derived from Micrococcus, it plays a crucial role in skincare with its excellent DNA repair capabilities. It effectively helps skin cells recover from damage caused by UV radiation and environmental stress, thereby strengthening the skin's natural repair mechanisms, enhancing its overall health and resilience. By accelerating the repair process of damaged DNA, it significantly reduces visible signs of skin damage, promotes collagen synthesis, and slows its degradation, while providing preventive protection for the skin.

    4. Panthenol (Pro-Vitamin B5)
      A recognized powerful moisturizing and soothing ingredient. It deeply penetrates the skin, helping to repair and strengthen the skin barrier function, significantly enhancing the skin's water retention capacity, reducing moisture loss, and keeping the skin soft, plump, and elastic. Additionally, Panthenol possesses excellent anti-inflammatory and reparative properties, effectively soothing irritated skin, accelerating wound healing, and reducing redness and discomfort.

    5. Arginine | Aspartic Acid | Glycine | Alanine | Valine | Proline | Threonine | Isoleucine | Histidine | Phenylalanine
      Ten amino acids with significant benefits for skin health. They are not only crucial for the synthesis of keratin, collagen, and elastic fibers, which helps to maintain the skin's structural integrity, strength, and elasticity, but also provide antioxidant benefits. Furthermore, they are key components of the skin's Natural Moisturizing Factor (NMF) that are vital for maintaining moisture, strengthening the skin's natural barrier function, and promoting a smooth, soft skin texture.

    6. Lemon Peel Powder | Lime Peel Powder
      Rich in Vitamin C, citric acid, flavonoids, and other active ingredients and powerful antioxidants, as well as excellent antioxidant, anti-inflammatory, and antibacterial properties. They can combat free radicals, calm and soothe redness and sensitivity, prevent blackheads and acne, and promote collagen production, thereby improving skin elasticity and tightening pores. Additionally, they help detoxify the skin, which helps to enhance skin health and vitality.

    7. Sodium Hyaluronate
      Hydrates, increases skin moisture content, and resolves dryness. It simultaneously forms a highly effective film on the skin's surface for long-lasting water retention and barrier repair.

    8. PCA | Sodium PCA
      Highly effective humectant and crucial component of the skin's Natural Moisturizing Factor (NMF), making them excellent hydrating ingredients. They can absorb moisture from the air and lock it into the skin, thereby increasing skin's moisture content, and helping to prevent dryness and dehydration.








  • Aqua, Alteromonas Ferment Extract, Propanediol, Panthenol, Glycerin, Citrus Limon (Lemon) Peel Powder, Soium PCA, Sodium Hyaluronate, Sodium Lactate, Cyanocobalamin, Arginine, Aspartic Acid, PCA, Glycine, Alanine, Citrus Aurantifolia (Lime) Peel Powder, Valine, Proline, Micrococcus Lysate, Threonine, Isoleucine, Histidine, Phenylalanine, Caprylyl Glycol, Sclerotium Gum, Ethylhexylglycerin, Levulinic Acid.