BERBERINE PLUS 2 or 3-BOX SET

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• DESCRIPTION
• HOW TO USE
• FAQ
• FULL INGREDIENTS

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Are you troubled by any of the following issues?

■ Continuous weight gain
■ Body fat accumulation, especially noticeable around the abdomen
■ Excessive visceral fat, leading to a continuously expanding waistline
■ Frequent bloating and water retention in the face and legs
■ Frequent consumption of carbohydrates
■ Concerned about blood sugar spikes after meals
■ Wants to stabilize blood sugar and prevent insulin resistance
■ Slow or stagnant metabolism, and a feeling of sluggish digestion
■ Low basal metabolic rate
■ Difficulty controlling appetite or always feeling hungry
■ Eating late-night snacks frequently, or overeating often
■ Want to sustainably manage weight
■ Want a natural weight loss product with a safe formula, not traditional diet pills
■ Hope to improve overall health while losing weight
■ Feel that the effects of common weight loss supplements on the market are not ideal

Weight Management Isn't Just for Beauty, It's for Health

As we know, excess fat accumulation around the waist, hips, face, and neck, can result in a lack of body definition, double chin, and puffy eyes and cheeks. Additionally, the chronic inflammation and oxidative stress associated with weight gain can cause poor skin texture, a dull complexion, and stretch marks. High body weight also puts pressure on joints and bones, affecting posture and movement, and can even lead to a hunched back.

However, weight gain isn't just an appearance issue——excess fat cells are like an out-of-control "inflammation factory," constantly releasing inflammatory signals and oxidative stress that trap the body in a state of chronic inflammation. This is more than just a number on the scale; it quietly erodes your health, increasing the risk of rising blood sugar, high cholesterol, cardiovascular disease, diabetes, osteoarthritis, and even cancer.

SHEGAIA partnered with Nutricare, a top Korean health food manufacturer with over 20 years of history, and after over 2 years of in-depth research and rigorous testing combining a variety of scientifically-proven natural extracts with cutting-edge safety manufacturing technology, created Berberine Plus, to simultaneously aid in weight loss, reduce fat and visceral fat, control blood sugar, prevent insulin resistance, alleviate bloating and water retention, and improve metabolism while boosting your basal metabolic rate!

The Berberine Plus Difference: A Synergistic Approach to Weight Management

Berberine Plus is not just a typical slimming supplement, but a comprehensive metabolic formula with a solid scientific foundation. It fundamentally changes how the body operates to achieve genuine and effective weight loss, reduce fat and visceral fat, control blood sugar, prevent insulin resistance, alleviate bloating and water retention, improve metabolism, and boost your basal metabolic rate, helping to transform your body constitution from the ground up!

The Metabolic Master Switch: Activating Your Fat-Burning Engine

Berberine Plus' core ingredient is Berberine, a potent botanical compound revered in traditional medicine. It acts as a powerful activator of AMP-activated protein kinase (AMPK)——the "master switch" that tells your cells to stop storing energy and start burning it. This not only helps you effectively utilize your body's fat reserves, but also promotes sustainable weight reduction and a more efficient metabolism, fundamentally reshaping your metabolic constitution.

Triple Fat-Burning Synergy: Precise Fat Conversion

SHEGAIA perfectly integrates potent metabolic activators to achieve a triple fat-burning effect. L-Carnitine, acting as a fatty acid transport vehicle, directly delivers fat into the cell's powerhouses——the mitochondria, to convert fat into abundant energy. This process significantly enhances the body's fat-burning capacity, while precisely reducing fat mass. Resveratrol, by activating the SIRT1 and AMPK pathways, induces fat browning, i.e. converting white fat into more easily burned beige fat, thereby increasing the body's resting energy expenditure. Furthermore, Quercetin simultaneously supports the AMPK pathway and effectively inhibits lipogenesis, while regulating lipid metabolism to reduce fat accumulation.

Targeted Abdominal Fat Reduction and Systemic Anti-Inflammation

Fat comes in different types. The formula combines two potent ingredients focused on improving visceral fat and inflammation. Moro Blood Orange Concentrated Powder, clinically proven and rich in anthocyanins, specifically targets and reduces stubborn abdominal fat. This is not just about the number on the scale; more importantly, it's about improving your body composition, helping you sculpt a firmer, leaner, more toned physique in the areas that matter most. Whilst, Quercetin, acting as a powerful anti-inflammatory and antioxidant component, inhibits chronic inflammatory factors in the body, alleviating the root cause of metabolic disorders, further supporting healthy weight management.

Say Goodbye to Blood Sugar Swings: Stabilizing Blood Sugar & Boosting Insulin Sensitivity

The various ingredients in the formula provide multi-layered and comprehensive support for maintaining healthy blood sugar levels and metabolic function. Firstly, Berberine, which effectively activates the metabolic master switch AMPK, directly enhances cellular sensitivity to insulin and reduces glucose production by the liver. Quercetin and Resveratrol are both proven to have insulin-sensitizing effects, while activating AMPK and improving inflammation, helping cells respond to insulin more effectively and utilize glucose. Whilst, Black Pepper Extract, by regulating AMPK and signaling, enhances the cell's ability to uptake glucose, synergistically stabilizing post-meal blood sugar with Berberine. Futhermore, Moro Blood Orange protects the insulin-secreting pancreatic cells and reduces insulin resistance caused by oxidative stress. L-Carnitine further aids blood sugar control by promoting glucose entry into muscle cells and enhancing fat burning. Additionally, Potassium Chloride, as a key electrolyte, ensures cells maintain normal ion balance and supports the proper secretion and action of insulin.

Gut Metabolism and Nutritional Enhancement

The formula contains potent factors that optimize metabolism starting from the gut. Black Pepper Extract acts as an excellent bioavailability enhancer, significantly increasing the body's absorption and utilization efficiency of ingredients like Berberine and Quercetin, allowing each dose to achieve maximum efficacy. Whilst, Quercetin helps reshape the gut microbiota, improving imbalances caused by high-fat diets, thereby supporting metabolic function from a gut health perspective.

Fluid Balance & Cellular Support: Restoring Lightness and Balance

Potassium Chloride, as a key electrolyte, gently helps the body excrete excess water and sodium, reducing water retention, swelling, and uncomfortable bloating, leading to a more toned appearance. Additionally, Magnesium Stearate, a vital mineral, further supports this balance while playing a key role in over 300 metabolic reactions, including blood sugar regulation and energy production, ensuring every cell is operating at its best.

Promoting Recovery and Rest: The Cornerstone of Success

Weight management isn't just about what you do or eat during the day——how your body recovers at night is also a critical key to success. Montmorency Tart Cherry Juice is rich in anti-inflammatory compounds and natural melatonin, which helps to reduce muscle soreness and inflammation for faster recovery. Paired with Resveratrol, their synergistic effects support deep, restorative, high-quality sleep, which helps regulate appetite-controlling hormones and prevents late-night hunger and metabolic dysfunction.

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Berberine






An active compound extracted from the Indian Barberry fruit. A large number of studies have confirmed its ability to provide multifaceted benefits for metabolic health through various mechanisms.


Fat Reduction & Weight Loss

Research shows that Berberine can lead to a significant reduction in body weight, BMI, and waist circumference through the following mechanisms:

【 AMPK Activation 】

Berberine's most prominent weight loss mechanism is the activation of AMP-activated protein kinase (AMPK). AMPK acts as a metabolic "master switch"; when activated, it signals cells to shift the body's metabolic state from storing energy (fat) to burning energy. This promotes fat breakdown, increases fat burning, reduces fat synthesis and storage, and boosts metabolic efficiency.

【 Inhibits Fat Cell Growth 】

On a molecular level, Berberine can inhibit the growth and proliferation of adipocytes (fat cells).

【 Regulates Appetite 】

Leptin is a hormone secreted by fat cells that primarily functions to induce satiety, regulate appetite, and control energy expenditure to maintain weight balance. A lack of Leptin or insufficient sensitivity to Leptin receptors, known as "Leptin Resistance", can lead to a failure to feel full, potentially causing weight gain. Berberine can lower leptin resistance and improve leptin sensitivity, allowing the brain to once again receive the "I'm full" signal, thereby regulating appetite. Additionally, studies show that Berberine can influence appetite-regulating hormones such as GLP-1, GLP-2, and PYY, which can reduce overeating that leads to weight gain.

【 Gut Health 】

The gut microbiome plays a crucial role in metabolism and body weight. Berberine can alter the gut microbiome and, by influencing the balance of gut bacteria, help reduce gut inflammation and improve metabolic function.


Increases Insulin Sensitivity and Stabilizes Blood Sugar Levels

Research shows that Berberine can significantly increase insulin sensitivity and stabilize blood sugar levels, even lowering blood sugar in patients with type 2 diabetes. Its effects on fasting blood glucose and long-term glucose indicators (like HbA1c) are often comparable to prescription medications, making it a highly regarded natural alternative or complementary therapy:

【 AMPK Activation 】

As mentioned previously, Berberine activates AMPK. The activation of AMPK makes cells more sensitive to insulin, allowing glucose to be more effectively absorbed from the bloodstream and used for energy.

【 Reduces Glucose Production 】

A major cause of high blood sugar is the overactivity of gluconeogenesis, the mechanism by which the liver produces glucose. Berberine helps suppress this process, further lowering blood sugar levels. This is particularly beneficial for patients with type 2 diabetes.

【 Slows Carbohydrate Absorption 】

Berberine can slow the breakdown of carbohydrates in the intestines, helping to mitigate post-meal blood sugar spikes.

【 Promotes Glycolysis 】

The process by which the body breaks down sugar within cells is called glycolysis. Berberine can stimulate glycolysis by increasing the activity of glucokinase, thereby increasing glucose breakdown and energy production.


Boosts Metabolism

【 Improves Metabolism and Basal Metabolic Rate 】

By activating AMPK, Berberine can effectively promote energy expenditure, thereby boosting metabolism. It also influences key metabolic pathways related to glucose and lipid (fat) metabolism. A more efficient metabolism not only aids in weight management but also boosts energy levels and lowers the risk of metabolic diseases (such as fatty liver disease and type 2 diabetes).


Improves Cholesterol

Studies show that Berberine can significantly lower total cholesterol, LDL cholesterol, and triglyceride levels, while also increasing "good" HDL cholesterol. These effects are crucial for cardiovascular health:

【 Inhibits Hepatic Lipid Synthesis 】

By activating AMPK, Berberine inhibits lipid synthesis in the liver and promotes their breakdown.

【 Increases LDL Receptor Expression 】

Berberine can increase the stability of low-density lipoprotein (LDL) receptor mRNA. This leads to more LDL receptors on the surface of liver cells, thereby enhancing the liver's ability to clear "bad" LDL cholesterol from the blood.

【 Inhibits Cholesterol Absorption 】

Berberine can interfere with the absorption of cholesterol in the intestines, significantly lowering total cholesterol.


Gut Health

By improving the gut environment, Berberine supports overall digestive health, reduces inflammation, and indirectly benefits other conditions such as diabetes and high cholesterol:

【 Antibacterial Properties 】

Berberine has powerful antibacterial effects that help to eliminate harmful bacteria and pathogens in the gut.

【 Regulates Gut Microbiota 】

Berberine can promote the growth of beneficial bacteria while reducing unwanted microorganisms, leading to a healthier and more diverse gut microbiome.

【 Reduces Inflammation 】

Berberine's anti-inflammatory properties protect the intestinal lining from inflammation, which is a key factor in many digestive diseases.


Anti-Inflammatory

By reducing chronic inflammation, Berberine helps manage the symptoms of inflammatory diseases and lowers the risk of conditions with inflammation at their core (such as heart disease and certain neurological disorders):

【 Inhibits Inflammatory Pathways 】

Inflammatory signaling pathways, such as NF-κB and AP-1, are responsible for producing pro-inflammatory proteins (cytokines) like TNF-α and IL-6. Berberine inhibits these key inflammatory signaling pathways.

【 Reduces Oxidative Stress 】

As an antioxidant, Berberine can neutralize free radicals, thereby reducing the oxidative stress that leads to cell damage and triggers inflammation.


Regulates Energy Levels

When the body can use fuel more efficiently, daily energy levels naturally increase, and feelings of fatigue decrease. This is especially beneficial for people who experience "metabolic fatigue" due to insulin resistance:

【 AMPK Activation 】

When Berberine activates AMPK, it boosts cellular energy production by increasing fat oxidation and glucose utilization.

【 Improves Blood Sugar Control 】

By preventing sharp blood sugar spikes and crashes, Berberine helps stabilize energy levels throughout the day and prevents the "energy crashes" associated with poor blood sugar control.


Improves Polycystic Ovary Syndrome (PCOS)

Research shows that Berberine has the potential to improve various markers in women with PCOS, including insulin and glucose levels. It can even help regulate menstruation and improve overall hormonal balance:

【 Improves Insulin Sensitivity 】

PCOS is often linked to insulin resistance. By improving insulin sensitivity, Berberine helps regulate hormone levels, reduce androgen production, and restore stable menstrual cycles.

【 Weight Management 】

The weight loss benefits of Berberine are particularly helpful for PCOS patients, as weight reduction often improves their symptoms.

【 Lipid Profile 】

Berberine's positive effects on cholesterol and triglyceride levels are beneficial for individuals with PCOS, who have a higher risk of cardiovascular disease.



Black Pepper Extract
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Black Pepper Extract (with Piperine as its main active ingredient) is a potent natural alkaloid. It is traditionally known for enhancing nutrient absorption, but in modern research, its mechanism of regulating metabolism and fighting inflammation makes it a key ingredient for weight management and blood sugar control:


Weight Management

By regulating the life cycle of fat cells, Piperine in Black Pepper Extract controls body weight at the source:

【 Inhibits Fat Cell Formation (Adipogenesis) 】

Piperine effectively interferes with the process of fat cell differentiation (Adipogenesis), fundamentally reducing the formation of fat cells and fat accumulation by downregulating the key transcription factor PPARγ.

【 Promotes Fat Burning 】

Piperine activates the cell's energy switch, AMPK, and promotes the expression of UCP1 (Uncoupling Protein 1), enhancing the body's thermogenesis and energy expenditure, breaking down stored fat into usable energy.

【 Accelerates Fat Breakdown (Lipolysis) 】

Black Pepper Extract helps break down stored body fat into glycerol, accelerating fat metabolism and utilization.


Enhances Insulin Sensitivity and Stabilizes Blood Sugar Levels

By modulating at the cellular level, Piperine effectively helps the body utilize glucose more efficiently:

【 Improves Insulin Sensitivity 】

By inhibiting metabolic inflammation associated with obesity, Piperine helps enhance the cell's responsiveness to insulin.

【 Stabilizes Blood Sugar Levels 】

Black Pepper Extract activates the AMPK pathway, promoting the translocation of the GLUT4 transporter to the cell membrane, increasing muscle uptake and utilization of glucose from the blood, thus effectively helping to lower blood sugar levels.


Activates AMPK and Metabolism

Piperine's core function is the activation of AMPK, hence it is often hailed as a potent metabolic regulator:

【 Direct Activation of the AMPK Pathway 】

Piperine is a powerful AMPK activator that switches on the cell's "burning mode." Activating AMPK increases fatty acid oxidation (fat burning) while inhibiting the synthesis of fat and glucose.

【 Accelerates Overall Metabolic Efficiency 】

By regulating the AMPK signaling pathway, Piperine optimizes the body's energy balance, allowing the body to consume energy more efficiently, which is crucial for long-term weight management.


Improves Cholesterol

【 Regulates Lipid Metabolism 】

Piperine is confirmed to improve dyslipidemia, helping to regulate lipid metabolism in the liver and blood.

【 Lowers Total Cholesterol and Triglycerides 】

Studies show that Piperine helps lower blood levels of Total Cholesterol (TC) and Triglycerides (TG), which has a positive effect on maintaining cardiovascular health.


Improves Gut Health

【 Bioavailability Enhancer 】

A unique benefit of Piperine is its role as a bioavailability enhancer. It inhibits enzymes in the gut that metabolize other nutrients, thereby significantly increasing the body's absorption efficiency of other ingredients in the formula (such as Berberine, Moro Blood Orange, etc.).

【 Immune Modulation 】

As an immune-modulating component, it helps balance the immune response within the gut, indirectly supporting a healthy gut environment.


Anti-inflammatory

By reducing chronic inflammation, Black Pepper Extract helps improve metabolic function and lowers the risk of inflammation-related diseases (such as heart disease):

【 Inhibits Inflammatory Response 】

Piperine possesses significant anti-inflammatory activity. By suppressing pro-inflammatory cytokines and regulating immune responses, it effectively reduces chronic low-grade inflammation in the body—the root cause of many metabolic diseases (such as obesity and diabetes).


Balances Energy Levels

【 Enhances Energy Utilization Efficiency 】

By activating AMPK and promoting fat burning, the body can more effectively convert fat into energy. This stable "fuel" supply helps maintain stable energy levels, avoiding the fatigue caused by blood sugar fluctuations.


PCOS (Polycystic Ovary Syndrome) Potential Benefits

【 Indirect Regulatory Effect 】

Given that PCOS is closely associated with severe insulin resistance and chronic inflammation, Piperine is a potent auxiliary ingredient for improving the metabolic symptoms of PCOS, thanks to its mechanisms for enhancing insulin sensitivity and powerful anti-inflammatory action.



Resveratrol
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Resveratrol is a well-known polyphenol compound mainly found in red grape skins, berries, and Japanese knotweed. It mimics the effects of calorie restriction and, by activating the longevity gene SIRT1 and key metabolic pathways, provides comprehensive metabolic, anti-inflammatory, and cardiovascular health benefits to the body:


Enhances Insulin Sensitivity and Stabilizes Blood Sugar Levels

Resveratrol has been proven to improve glucose homeostasis, especially in individuals with metabolic abnormalities:

【 Improves Insulin Resistance 】

Resveratrol improves cellular response to insulin, reducing insulin resistance and fat accumulation caused by high-calorie diets.

【 Protects Pancreatic $\beta$-Cells 】

Resveratrol helps maintain the function of pancreatic β-cells, which are responsible for insulin secretion, thereby helping to stabilize blood sugar levels.

【 Mitigates Oxidative Stress 】

The powerful antioxidant properties of Resveratrol reduce the oxidative stress that leads to impaired insulin signaling.


Activates AMPK and Metabolism

The activation of longevity genes and metabolic pathways by Resveratrol is its core value:

【 Activates SIRT1 and AMPK 】

Resveratrol is a well-known SIRT1 activator. SIRT1 is the longevity gene associated with metabolic health and cell repair. Activation of SIRT1 in turn promotes the phosphorylation of AMPK, akin to switching on the cell's "fat-burning switch."

【 Enhances Mitochondrial Function 】

By activating these key pathways, Resveratrol promotes Mitochondrial Biogenesis, enhancing the cell's energy production capacity and efficiency, thereby improving overall metabolic function.


Improves Cholesterol and Cardiovascular Health

【 Regulates Lipid Metabolism 】

Resveratrol helps improve lipid (fat) homeostasis, reducing fat accumulation in the liver (fatty liver).

【 Lowers Undesirable Cholesterol 】

Studies show that Resveratrol helps lower plasma levels of Triglycerides (TG), Total Cholesterol, and LDL-C ("bad" cholesterol) while increasing HDL-C ("good" cholesterol) levels.

【 Cardiovascular Protection 】

Through its antioxidant and anti-inflammatory effects, Resveratrol prevents the formation of atherosclerotic plaques, making it extremely beneficial for the cardiovascular system.


Anti-inflammatory

【 Potent Antioxidant and Anti-inflammatory 】

As a polyphenol, Resveratrol possesses exceptional antioxidant and anti-inflammatory properties. It inhibits inflammatory factors and alleviates chronic low-grade inflammation, which is essential for improving inflammatory states associated with metabolic syndrome.


PCOS (Polycystic Ovary Syndrome) Potential Benefits

【 Hormonal and Metabolic Regulation 】

Given that PCOS involves insulin resistance, hyperandrogenism, and inflammation, Resveratrol's potential for improving insulin sensitivity, anti-inflammatory effects, and estrogen modulation makes it a popular ingredient for improving the metabolic and endocrine disorder symptoms of PCOS.



Moro Orange






Moro Orange is a special variety of blood orange known for its deep red flesh. This vibrant color comes from its high concentration of anthocyanins, a class of powerful antioxidants. While the fruit itself has general health benefits, its concentrated extract is a key ingredient in many supplements and is highly effective for metabolic health and weight management:


Fat Reduction & Weight Loss

Multiple clinical trials show that Moro orange extract, when combined with a healthy diet and exercise, leads to significant reductions in body weight, BMI, waist circumference, hip circumference, and overall fat mass compared to placebo groups.

【 Inhibits Fat Accumulation 】

Moro orange extract can directly impact the metabolism of fat cells (adipocytes). Studies show that its anthocyanins, particularly cyanidin-3-glucoside (C3G), can inhibit genes and enzymes related to fat formation and storage. This means taking Moro orange extract makes the body less likely to accumulate fat, especially in stubborn areas.

【 Promotes Fat Burning 】

Research indicates that compounds in Moro orange can increase the expression of genes involved in fatty acid breakdown. Simply put, it signals the body to burn fat for energy instead of storing it, thus achieving weight loss.

【 Targets Abdominal Fat 】

Clinical studies specifically show that taking Moro orange extract can significantly reduce abdominal fat, including both subcutaneous fat (the fat you can pinch) and visceral fat (the dangerous fat surrounding organs).


Blood Sugar Control & Insulin Sensitivity

【 Reduces Oxidative Stress 】

The anthocyanins in Moro orange are powerful antioxidants that reduce the oxidative stress associated with insulin resistance. By alleviating this key factor, cellular sensitivity to insulin can be improved.

【 Reduces Liver Fat 】

Moro orange helps prevent fatty liver disease, a condition closely linked to poor insulin sensitivity and type 2 diabetes.


Boosts Metabolism

【 Metabolic State Shift 】

By inhibiting fat storage and promoting fat burning, Moro orange shifts the body's metabolic state towards a more efficient "fat-utilizing" mode. This is often referred to as improving "metabolic flexibility," where the body can more easily switch between different fuel sources. When overall metabolism is more efficient, it naturally leads to better weight and energy level management.


Supports Cardiovascular Health

【 Reduces Oxidative Stress 】

Chronic inflammation and oxidative stress are major drivers of atherosclerosis (plaque buildup in the arteries). The anti-inflammatory and antioxidant properties of Moro orange help protect blood vessels from damage by reducing chronic inflammation and neutralizing free radicals.

【 Regulates Lipid Metabolism 】

Studies show that Moro orange helps lower serum triglyceride and total cholesterol levels, thereby improving the lipid profile and reducing the risk of heart disease.



L-Carnitine






L-Carnitine is an amino acid derivative. Unlike ingredients that directly stimulate metabolism, L-Carnitine acts as a "cellular shuttle," responsible for transporting fatty acids to be burned for fuel inside cells. A report combining 37 studies indicated that L-Carnitine supplementation can significantly reduce body weight, BMI, and fat mass, making it an essential ingredient for a focus on fat reduction and metabolic efficiency:


Fat Reduction & Weight Loss

【 Enhances the Body's Ability to Burn Fat 】

L-Carnitine's primary function is to transport long-chain fatty acids into the mitochondria (the cell's "powerhouses"). Once inside, these fatty acids are oxidized and converted into energy. By increasing this fatty acid transport, L-Carnitine boosts the body's ability to burn fat. When combined with exercise and a healthy diet, it can lead to more significant fat reduction than diet and exercise alone.

【 Indirectly Affects AMPK 】

Research shows that L-Carnitine can indirectly influence the AMPK pathway. By shifting the body's fuel source from glucose towards fatty acids, it creates a metabolic state that supports a healthier, more efficient metabolism.


Metabolism & Energy

【 Boosts Energy Production 】

By promoting the transport of fatty acids into the mitochondria, L-Carnitine ensures the body more effectively uses fat for a stable and efficient fuel source, thereby boosting energy production at a cellular level. This not only improves metabolism but also enhances athletic performance and increases overall vitality.


Regulates Blood Sugar & Insulin Sensitivity

【 Boosts Energy Production 】

Studies show that because L-Carnitine enhances fat utilization, it reduces the need for glucose as the primary fuel source. This can increase glucose uptake into muscle cells, improving glucose metabolism and enhancing the body's response to insulin. This helps manage blood sugar levels and aids in the prevention of insulin resistance and metabolic diseases.



Quercetin
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Quercetin is a natural flavonoid compound widely found in fruits and vegetables like apples, onions, and berries, and is recognized as one of the most potent antioxidants and anti-inflammatory agents. By regulating cellular signaling pathways, it offers multiple protective effects against chronic diseases and metabolic disorders, excelling particularly in improving insulin resistance and supporting female endocrine health.


Weight Management

Quercetin's main role in weight management is through regulating fat metabolism and cellular signaling:

【 Improves Fat Metabolism 】

Quercetin can improve lipid metabolism by regulating signaling pathways like AMPK/PPAR. Studies show it can effectively reduce abdominal fat percentage and hepatic lipid accumulation.

【 Induces Fat Browning 】

Research indicates that Quercetin can stimulate the conversion of white fat into beige fat (fat browning) by activating the AMPK pathway. Since this is a mechanism that increases thermogenesis and energy expenditure, it helps combat obesity.

【 Reduces Fat Accumulation 】

By regulating gene expression, Quercetin helps reduce the accumulation of lipids and triglycerides in fat cells.


Enhances Insulin Sensitivity and Stabilizes Blood Sugar Levels

Quercetin exhibits effects similar to the drug Metformin in improving blood sugar control:

【 Improves Insulin Resistance 】

Quercetin can significantly improve insulin resistance and lower plasma biomarkers associated with diabetes, including insulin and Leptin levels.

【 Lowers Blood Sugar Indicators 】

Systematic reviews and meta-analyses show that Quercetin can effectively lower key indicators such as fasting insulin, fasting blood glucose (FBG), and HOMA-IR (Insulin Resistance Index).

【 Enhances Signal Transduction 】

Quercetin can exert an insulin-sensitizing effect by enhancing insulin signal transduction (e.g., boosting protein expression and tyrosine phosphorylation of insulin).


Activates AMPK and Metabolism

【 Activates the AMPK Pathway 】

Quercetin is a regulator of AMPK. Activating AMPK enhances the metabolism of lipids and glucose and reduces lipid synthesis, which is key to improving metabolic disorders and insulin resistance.

【 Regulates Lipid Metabolism Genes 】

By regulating the AMPK/PPAR signaling pathway, Quercetin can downregulate gene expression related to fat synthesis, helping to maintain a healthier metabolic state.


Improves Cholesterol

【 Improves Dyslipidemia 】

Quercetin has the potential to positively improve dyslipidemia.

【 Lowers Undesirable Blood Lipids 】

Multiple studies, including meta-analyses targeting PCOS patients, show that Quercetin can effectively lower levels of Total Cholesterol and Triglycerides, contributing to cardiovascular protection.


Improves Gut Health

【 Reshapes Gut Microbiota 】

Quercetin is capable of restoring gut microbiota imbalance caused by high-fat diets, altering the distribution of intestinal bacteria.

【 Increases Beneficial Bacterial Abundance 】

Quercetin is proven to significantly increase the relative abundance of the beneficial gut bacterium *Akkermansia muciniphila* (colloquially known as the "fat-killing bacterium") while decreasing the Firmicutes/Bacteroidetes ratio associated with metabolic disorders, thereby supporting gut barrier function and metabolic health.


Anti-inflammatory

【 Excellent Anti-inflammatory and Antioxidant Properties 】

Quercetin's most widely known function is its powerful anti-inflammatory and antioxidant action. It effectively neutralizes free radicals, reducing oxidative stress—a driving factor in many chronic diseases and metabolic dysfunction.

【 Inhibits Inflammatory Pathways 】

Quercetin can modulate key molecular pathways such as NF-κB and MAPK, thereby inhibiting the production and release of pro-inflammatory cytokines, effectively relieving systemic and metabolic inflammation.


Balances Energy Levels

【 Indirect Performance Enhancement 】

Through its anti-inflammatory effects (reducing factors of chronic fatigue), improved blood sugar stability (avoiding energy crashes), and AMPK activation (enhancing cellular energy efficiency), Quercetin helps maintain stable physiological function, indirectly supporting and balancing energy levels throughout the day.


PCOS (Polycystic Ovary Syndrome) Potential Benefits

Quercetin shows immense potential in regulating the metabolic and endocrine pathology of PCOS:

【 Regulates Endocrine Axis 】

Quercetin can modulate the hypothalamus-pituitary-ovary axis, lowering levels of Testosterone and Luteinizing Hormone (LH), as well as the LH/FSH ratio. This helps improve hyperandrogenism and ovulation disorders.

【 Ameliorates Metabolic Complications 】

Quercetin can significantly improve insulin resistance, dyslipidemia, and oxidative stress in PCOS patients. This is crucial for treating PCOS-related metabolic complications.



Potassium Chloride
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Potassium chloride is an essential mineral and electrolyte crucial for many bodily functions. Unlike nutrients that directly target fat burning or metabolic pathways, potassium chloride focuses on maintaining internal balance, and helps efficiently alleviate bloating and water retention:


Reduces Bloating and Water Retention

【 Regulates Potassium and Sodium Balance 】

The body's fluid balance is a delicate equilibrium of water and electrolytes, primarily sodium and potassium. Sodium is the main electrolyte in extracellular fluid, while potassium is the main electrolyte in intracellular fluid. A key protein on the cell membrane, the Sodium-Potassium Pump, actively pumps sodium out of the cell and potassium into the cell. As the primary intracellular electrolyte, potassium draws water into the cells, ensuring they are properly hydrated. In contrast, sodium retains water in the extracellular fluid (such as blood plasma and interstitial fluid). A high-sodium, low-potassium diet disrupts this balance——when there is too much sodium and not enough potassium, the body retains water in extracellular spaces, leading to bloating, water retention, and swelling in the face, arms, lets, and abdomen. Taking potassium chloride helps restore the correct electrolyte balance, and allow the kidneys to excrete excess sodium and water, thereby reducing bloating, water retention, and the heavy feeling and discomfort in the abdomen, resulting in a more toned and streamlined physique.


Improves Metabolism & Energy

【 Electrolyte Function 】

Many metabolic reactions in the body are catalyzed by enzymes. These enzymes function best in a properly hydrated cellular environment. Dehydration can impair enzyme function, slowing down metabolic processes like the breakdown of fats (lipolysis) and carbohydrates, as well as waste removal from cells. As a key electrolyte, potassium helps ensure the body is well-hydrated by maintaining the sodium-potassium balance inside and outside cells. This ensures that glucose and fatty acids can smoothly enter cells to produce energy. Furthermore, the concentration gradient between potassium and sodium is central to maintaining nerve and muscle function, which directly impacts physical activity and energy expenditure.


Supports Blood Sugar Regulation and Improves Insulin Sensitivity

【 Regulates Insulin 】

Potassium helps promote glucose uptake into cells. Low potassium levels can impair the pancreas's ability to release insulin and may also reduce cellular sensitivity to insulin, which can lead to elevated blood sugar levels. Therefore, potassium's role in blood sugar regulation is indirect but indispensable.

【 Prevents Insulin Resistance 】

By helping to maintain healthy potassium levels, potassium chloride provides foundational support for the body's ability to regulate blood sugar and improve insulin sensitivity, which helps prevent insulin resistance and manage conditions like prediabetes and type 2 diabetes.


Regulates Blood Pressure

【 Lowers Blood Pressure 】

Potassium chloride's main cardiovascular benefit is lowering blood pressure by helping the body excrete excess sodium. Although it doesn't directly affect issues like cholesterol, maintaining healthy potassium levels is one of the keys to cardiovascular health, as blood pressure is a major factor in heart health.



Montmorency Tart Cherry Juice






Unlike sweet cherries, Montmorency tart cherry juice is rich in powerful antioxidants and anti-inflammatory compounds like anthocyanins and melatonin. It serves as a crucial cornerstone of metabolic health, aiding in weight management:


Fat Reduction & Weight Loss

【 Regulates Gene Expression Related to Fat Metabolism 】

Montmorency tart cherry has the ability to regulate gene expression related to fat metabolism and improve other metabolic markers, thereby reducing abdominal fat and overall fat mass (fat storage).

【 Anti-inflammatory Properties 】

The anti-inflammatory properties of Montmorency tart cherry combat the chronic inflammation often associated with obesity, putting the body in a state more conducive to weight loss.


Blood Sugar Control & Insulin Sensitivity

【 Inhibits Carbohydrate-Breaking Enzymes 】

Studies show that the anthocyanins and other phenolic compounds in Montmorency tart cherry can inhibit certain enzymes responsible for breaking down carbohydrates, thereby slowing glucose absorption and preventing blood sugar spikes.

【 Improves Insulin Sensitivity 】

The antioxidant properties of Montmorency tart cherry protect the insulin-producing cells in the pancreas, which helps improve insulin sensitivity.


Improves Metabolism

【 Promotes Healthy Gut Microbiome 】

The polyphenols and other compounds in Montmorency tart cherry can have a positive effect on the gut microbiome. As a food source for beneficial bacteria, these compounds help promote a healthy, balanced gut microbiome, which is linked to reduced inflammation and improved metabolic function.

【 Improves Sleep Quality 】

Getting high-quality sleep is crucial for weight management, as sleep deprivation can disrupt appetite-controlling hormones like ghrelin and leptin, leading to increased appetite and greater fat storage. Montmorency tart cherry is a natural source of melatonin, the hormone that regulates the sleep-wake cycle, and helps improve sleep quality. This, in turn, regulates ghrelin and leptin, and helps reduce fat storage.

【 Supports Cellular Function 】

By reducing inflammation and oxidative stress and improving sleep, Montmorency tart cherry enhances the function of various cells in the body, thus creating a more efficient metabolic state.

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The Difference: Why Berberine Plus Outperforms Others

The market is flooded with various slimming products, but have you ever wondered why their results are often so disappointing?

SHEGAIA understands that only through solid scientific research and a potent formula can metabolic issues truly be solved. That's why our formula doesn't blindly follow trends by using common ingredients that are weakly effective or lack solid evidence. After countless research verifications, Berberine Plus work through multiple core mechanisms to address a wider range of metabolic health issues, fundamentally reshaping your metabolic constitution to deliver significant and lasting results in fat reduction, blood sugar control, and de-bloating:

• Activates the AMPK metabolic master switch to promote fat burning
• Inhibits fat cell growth and accumulation, especially stubborn visceral fat
• Stabilizes blood sugar and reduces glucose production in the liver
• Boosts insulin sensitivity, addressing the root of the problem
• Restores proper electrolyte balance, say goodbye to water retention
• Improves gut microbiome and internal inflammatory response

In contrast, the effects of common slimming ingredients on the market are often mild, weak, or completely lacking:

• Garcinia Cambogia
  
  The active ingredient in Garcinia Cambogia, hydroxycitric acid (HCA), claims to block carbohydrates from converting to fat and help suppress appetite. However, scientific research on its effectiveness is mixed. Many human studies show that its weight loss effects are minimal, with no significant difference from a placebo, and there is insufficient evidence to support its appetite-suppressing claims. Overdosing may also lead to digestive discomfort.
  
  
• Catechins
  
  Catechins, particularly EGCG (Epigallocatechin gallate) from green tea extract, can slightly boost metabolism and fat burning. However, this effect is generally mild and only becomes more noticeable when combined with other factors like exercise. Many studies indicate that its impact on weight loss is small, making it difficult to achieve significant results on its own.
  
  
• Coleus Forskohlii
  
  Forskolin, the main active compound in Coleus Forskohlii, claims to "theoretically" activate adenylate cyclase to stimulate fat breakdown and metabolism. However, human studies on its weight loss effects are inconsistent, and most results are not significant. Some research suggests it helps with weight maintenance, but there is a lack of strong evidence for direct weight loss.
  
  

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Berberine Plus Key Benefits

✓ Helps with healthy weight loss
✓ Significantly reduces fat mass and visceral fat
✓ Potently controls and stabilizes blood sugar levels
✓ Boosts insulin sensitivity
✓ Improves metabolic efficiency
✓ Activates the body's fat-burning engine
✓ Precisely targets and reduces abdominal fat
✓ Inhibits cholesterol absorption
✓ Lowers total cholesterol, LDL cholesterol, and triglyceride levels
✓ Eases abdominal bloating and discomfort
✓ Relieves swelling and water retention
✓ Restores proper electrolyte balance
✓ Improves gut microbiome ecology
✓ Reduces inflammation and oxidative stress
✓ Promotes restorative sleep

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The serving size for Berberine Plus is 1 sachet, with 3 pills per sachet (to be taken all at once). The maximum dosage is 1 sachet before each meal, for a maximum of 3 times a day.

The formula offers unique flexibility, allowing you to choose the best schedule based on your lifestyle, dietary habits, and weight loss goals to achieve optimal results.

Active Weight Loss & Comprehensive Control Phase

For the active weight loss phase, or if you need to achieve your goals in a short period of time, have significant metabolic issues, are travelling for holiday, eat out a lot, or require more powerful blood sugar control, we recommend taking it three times a day, 30 minutes before breakfast, lunch, and dinner. This maximizes the ingredients' effectiveness, providing your body with the most comprehensive metabolic control, while maximally suppressing carbohydrate absorption, preventing blood sugar spikes all day, and keeping your body in a continuous fat-burning mode.

• Taken on an empty stomach 30 minutes before breakfast
  Morning is the golden time to restart your metabolism. Taking it on an empty stomach 30 minutes before breakfast effectively activates your body's fat-burning engine, while initiating fat-burning mode, and promoting fat reduction and de-bloating. It also stabilizes blood sugar at the start of the day, controls appetite, and reduces morning hunger.
  
  
• Taken on an empty stomach 30 minutes before lunch and dinner
  Taking it on an empty stomach 30 minutes before lunch and dinner effectively suppresses appetite, inhibits carbohydrate absorption, blocks fat storage, and maximally prevents sharp post-meal blood sugar spikes, while also reducing the need for afternoon tea or late-night snacks.
  
  
• If you forget to take it before a meal
  If you forget to take it on an empty stomach 30 minutes before a meal, you can choose to take it as soon as possible after eating.
  
  
• When you only eat one or two meals a day
  Berberine Plus is different from other slimming products that simply block calorie absorption, and thus the key to optimal results is taking a consistent, regular dose. While the ideal scenario is to take it 30 minutes before each of your three daily meals, if you are having only one or two meals on a particular day, spread out the remaining doses throughout the day. For example, if you are having only one meal in a day, take the first dose with that meal, and then take the remaining two doses in the evening and before bed; if you are having only two meals, then take the third dose before bed.
  
  

General Weight Loss & Continuous Support

For general weight loss or to receive continuous metabolic support, we recommend taking it twice a day, 30 minutes before breakfast and dinner. This method ensures your body starts the day in a high-efficiency metabolic mode and provides precise control during the dinner period, which is often the peak time for calorie intake.

• Take on an empty stomach 30 minutes before breakfast
  Morning is the golden time to restart your metabolism. Taking it on an empty stomach 30 minutes before breakfast effectively activates your body's fat-burning engine, while initiating fat-burning mode, and promoting fat reduction and de-bloating. It also stabilizes blood sugar at the start of the day, controls appetite, and reduces morning hunger.
  
  
• Take on an empty stomach 30 minutes before dinner
  Taking it on an empty stomach 30 minutes before dinner effectively suppresses appetite, inhibits carbohydrate absorption, blocks fat storage, and maximally prevents sharp post-meal blood sugar spikes, while also reducing the need for late-night snacks.
  
  
• If you forget to take it before a meal
  If you forget to take it on an empty stomach 30 minutes before a meal, you can choose to take it as soon as possible after eating.
  
  
• When you only eat one meal a day
  Berberine Plus is different from other slimming products that simply block calorie absorption, and thus the key to optimal results is taking a consistent, regular dose. While the ideal scenario is to take it 30 minutes before breakfast and dinner, if you are having only one meal on a particular day, take the first dose with that meal, and then take the second dose before bed.
  
  

Basic Maintenance

Once you have reached your weight loss goal or simply want basic metabolic maintenance, we recommend taking one dose a day before your largest meal (you can choose between lunch or dinner according to your eating habits). This precisely controls blood sugar fluctuations and fat storage for that meal while also providing a fat-burning effect and basic metabolic support to help maintain a healthy physique.

• Take on an empty stomach 30 minutes before lunch or dinner
  Taking it on an empty stomach 30 minutes before dinner effectively suppresses appetite, inhibits carbohydrate absorption, blocks fat storage, and maximally prevents sharp post-meal blood sugar spikes.
  
  
• If you forget to take it before a meal
  If you forget to take it on an empty stomach 30 minutes before a meal, you can choose to take it as soon as possible after eating.
  
  

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For "Active Weight Loss & Comprehensive Control Phase" or "General Weight Loss & Continuous Support Phase", it is best to continue for at least 3 months or until the weight loss goal is achieved, in order to fundamentally optimize body cells and organ functions, and improve metabolism. Afterwards, follow the "Basic Maintenance" method to solidify the initial results and maintain long-term metabolic health and weight management.

Should you also wish to break down gluten and carbohydrates, promote digestion, rebuild the gut microbiome, suppress inflammatory substances in the gut and body, soothe intestinal discomfort, inhibit bad bacteria growth, nourish and strengthen the intestinal wall, prevent "leaky gut syndrome," and continuously improve the gut environment, combine withSHEGAIA Gluten SlimCut for optimal results!

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Q: Who is not suitable to take this product?

A: This product is not suitable for individuals who are pregnant or breastfeeding. Additionally, while the ingredients are commonly used in the treatment of prediabetes or diabetes, the formula can lower blood sugar and blood pressure. Therefore, individuals who are taking blood sugar and/or blood pressure medication must first consult your doctor.

Q: Can I take this if I have naturally low blood sugar?

A: If your blood sugar is below average even after meals, it is recommended to avoid taking this to prevent hypoglycemic symptoms. If you only experience low blood sugar occasionally when hungry, you can choose to take it after a meal.

Q: How long does it take to see results?

A: Everyone's body, metabolism, daily diet, and other factors are different, so it is difficult, and unrealistic, to give a one-size-fits-all answer. However, generally speaking, the formula can bring about changes in two phases——rapid, noticeable initial effects and deep metabolic re-shaping that takes time.

Initial Effects (within approximately 3 to 5 days): Many users can feel the initial effects within 3 to 5 days of starting to take the product. This is mainly reflected in the improvement of bloating, swelling, and abdominal discomfort. When excess water and sodium are excreted, the body feels lighter and the abdomen feels more comfortable. In addition, as blood sugar and hunger pangs begin to come under control, post-meal energy crashes and overeating issues will also start to improve.

Long-Term Effects (after two to several weeks): The true core metabolic transformation takes more time. Processes such as weight loss, fat reduction, blood sugar control, and improved insulin sensitivity—these deep body re-shaping effects usually become apparent with continuous use. During this time, Berberine will begin to fully activate AMPK and work synergistically with ingredients like L-Carnitine and Moro Orange to fundamentally boost the body's fat-burning efficiency.

Continuous use not only solidifies the initial effects but also brings about lasting metabolic health and weight management results.

Q: Can I stop taking it after reaching my target weight?

A: Berberine Plus was developed to help you build a healthier body. As a "metabolic toolbox" or "accelerator" on your weight loss journey, it helps you reach your goals more efficiently. Once you have reached your ideal weight and have established healthy eating and exercise habits, you can choose to gradually reduce the dosage or stop taking it based on your personal situation.

On the other hand, even after reaching your goal, you can still consider continuing to take it, because the true value of Berberine Plus extends far beyond short-term weight loss——long-term use can provide your body with continuous support to build a healthy, efficient, and resilient metabolism that is less prone to rebound, including:

• Helping the body stay in a high-efficiency fat-burning state
• Maintaining stable blood sugar and healthy insulin sensitivity
• Preventing the accumulation of stubborn abdominal fat and dangerous visceral fat
• Continuously fighting internal inflammation, thereby reducing the risk of various chronic diseases at the source
• Solidifying gut health and digestive function, and continuously nourishing beneficial gut bacteria to provide a stable foundation for the metabolic system
  
  

Q: Will I regain weight after I stop taking it?

A: If you stop taking it but maintain healthy eating and exercise habits, you should not experience any rebound. The reason for weight rebound is usually not because you stopped taking a supplement, but because you returned to your previous unhealthy lifestyle.

Imagine that Berberine Plus helped you reach your target weight through fat burning, blood sugar stabilization, appetite control, and reduced water retention. If you stop taking it but also return to your old habits, such as overeating, consuming excessive calories and foods that cause blood sugar spikes, and living a sedentary lifestyle, your body will naturally revert to its original state without the extra support, and your weight will rebound.

Q: Are there any side effects?

A: The Berberine Plus formula uses natural ingredients that have been verified by scientific research, and our advanced production management system ensures that every step, from raw material selection to final packaging, undergoes strict quality control. At the same time, the product and its production line have passed rigorous domestic and international standard inspections, ensuring that every batch of the product is safe and trustworthy.

Therefore, when taken at the recommended dosage and method, the product generally will not cause side effects, such as diarrhea or abdominal pain.

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Microcrystalline Cellulose, Indian Barberry Fruit Extract (with 30% Berberine), Potassium Chloride, Hydroxypropyl Methylcellulose, Calcium Carboxymethylcellulose, Magnesium Stearate, Silicon Dioxide, L-Carnitine, Black Pepper Extract, Korean Moro Orange Concentrated Powder, Resveratrol, Quercetin, Polish Montmorency Tart Cherry Juice Powder, Sucralose.

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