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How Does the Body Get Chronically Inflamed and How Does That Affect The Skin?

Home   The Journal   How Does the Body Get Chronically Inflamed and How Does That Affect The Skin?

March 19, 2025

When the skin shows signs of sensitivity, redness, acne, hives, eczema, rosacea, and other inflammatory issues, many people tend to rely solely on skincare products and creams prescribed by dermatologists to address the issues at hand.

Yes, skincare products or prescibed creams can indeed improve symptoms and are a crucial aspect to treat symptoms, but many overlook the fact that inflammatory skin issues are actually warning signs of chronic inflammation in the body! If the underlying chronic inflammatory issues are not addressed, not only will skin inflammation persists, but they may also worsen over time, while gradually damaging other systems in the body and evolving into chronic conditions such as diabetes, hypertension, cardiovascular diseases, and more!

Let us break down why the body experiences chronic inflammation and how it negatively impacts the skin!







When the body's immune system continuously secretes pro-inflammatory cytokines to counterbalance long-term stimuli, the body will experience chronic inflammation. This condition can be caused by single or multiple factors and circumstances, common ones include:


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    • Persistent Infections
      When the body is infected with bacteria or viruses for an extended period, this persistent infection state may lead to the immune system remaining active to combat the source of infection. This triggers long-term immune responses and continuous release of inflammatory mediators, resulting in chronic inflammation in the body, potentially damaging surrounding tissues and organs.

    • Autoimmune Diseases
      Autoimmune diseases, such as lupus, involve the immune system mistakenly recognizing normal body tissues as foreign invaders and attacking them. This overactive immune response continues to trigger inflammation and keeps the body in a state of chronic inflammation.

    • Chronic Diseases
      Diseases like diabetes, cardiovascular diseases, arthritis, insulin resistance, and many others, may lead to the continuous release of inflammatory mediators that keeps the body in a state of chronic inflammation.

    • Obesity
      Obesity is closely linked to chronic inflammation in the body because fat cells in adipose tissue release pro-inflammatory cytokines that stimulate the immune system, causing ongoing inflammatory responses in the body. This chronic inflammation may further exacerbate health issues related to obesity.

    • Poor Diet
      A daily diet high in oils, sugars, processed foods and unhealthy fats, as well as low in fiber, can stimulate the immune system, leading to increased inflammation in the body and chronic inflammation. Over time, this can damage the functionality of various body systems.

    • Frequent Consumption of Certain Foods
      Some foods, such as dairy, gluten, sugars, nightshades (including potatoes, tomatoes, peppers, eggplants, etc.), soy, alcohol, coffee, are prone to inducing chronic inflammation in different organs of the body. For more information, please visit: How Different Foods Negatively Affect the Skin and How Different Foods Negatively Affect the Skin - Part 2.

    • Stress · Lack of Sleep · Poor Sleep Quality
      Long-term stress, lack of sleep or poor sleep quality stimulate the body to release stress hormones like cortisol, leading to chronic inflammatory responses which gradually negatively impact various body systems and increase the risk of chronic diseases.

    • Environmental Factors
      Pollutants, chemicals, toxins, and allergens in the air and around us can stimulate the body's immune system, triggering chronic inflammation in the body and affecting health.

    • Unhealthy Lifestyle
      Lack of exercise, smoking, and other unhealthy lifestyle choices can affect immune system function and make the body more susceptible to inflammation, leading to a continuous state of inflammation in the body.

    • Aging
      As the body ages, its ability to regulate inflammation decreases, leading to "inflammaging," which refers to a state of chronic low-grade inflammation. This condition increases the likelihood of developing chronic diseases and accelerates the aging of various organs in the body.







    Of course, skin inflammations such as acne, contact dermatitis, and others are not necessarily caused by chronic inflammation in the body. However, due to the complex connections between the body's immune system, inflammatory responses, and skin health, when the body is in a state of chronic inflammation, not only does it bring various negative effects to the skin, but issues like acne and contact dermatitis caused by external factors can also become more severe.

    During such times, the correct approach is to use specific effective anti-inflammatory, antibacterial, and antiviral skincare products to alleviate and improve various external inflammatory symptoms, while also addressing internal inflammation reduction.

    Below are potential impacts on the skin due to chronic inflammation in the body:


    |Inducing or Aggravating Various Skin Inflammatory Issues


    Inflammation is a natural immune response in the body, used to protect the body from external factors. However, chronic inflammation in the body can overstimulate the immune system, leading to excessive activation of mast cells and the over-production of inflammatory cytokines, resulting in elevated levels of inflammatory mediators. This can induce or aggravate various skin inflammatory issues such as acne, eczema, psoriasis, rosacea, dermatitis, and more.

    Furthermore, when mast cells are overly active and inflammatory mediators are triggered, the skin becomes more sensitive to environmental factors and reacts more rapidly, leading to increased occurrences of hives, redness, swelling, sensitivity, and itching. In severe cases, it can lead to the emergence of new problems, including allergic reactions to things that were previously encountered without issues, such as dust, cotton fibers, humidity, and more.

     

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    | Aggravating Acne, Pimples, and Blackhead


    Sebum is an oily substance produced by the sebaceous glands in the skin that plays a crucial role in maintaining skin moisture and overall body health. However, chronic inflammation in the body can increase sebum production and alter the structure of sebum, thereby aggravating acne, pimples, and blackhead issues:


    • Increased Sebum Production
      Chronic inflammation in the body can stimulate the sebaceous glands to produce more sebum, making the skin more prone to oiliness.

    • Changes in Sebum Composition and Quality
      Sebum is composed of triglycerides, waxes, squalene, fatty acids, and cholesterol. Chronic inflammation in the body can lead to changes in the types and proportions of fatty acids in sebum. For example, the beneficial linoleic acid (omega-6 fatty acid) decreases while the thicker, oilier oleic acid (omega-9 fatty acid) that easily clogs pores increases.

    • Deterioration of Sebum Quality
      When the proportion of linoleic acid decreases and oleic acid increases in our sebum, its quality deteriorates, leading to a greasier, heavier feel that is more prone to oxidation. In addition, poor-quality sebum makes it easier for bacteria to grow, leading to clogged pore blockages, pimples, blackheads, and acne issues on the skin.

    • Presence of Inflammatory Mediators in Sebum
      Inflammatory mediators produced during chronic inflammation in the body may be present in our sebum. These mediators can further contribute to acne, pimples, and various skin inflammatory issues.


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    | Damaging the Skin Barrier Water Retention and Protection Function


    The skin barrier plays a crucial role in protecting the skin from external irritants, allergens, and pathogens, as well as in maintaining skin moisture. Chronic inflammation in the body gradually damages the function of this natural barrier of the skin. When the barrier is compromised, the skin's ability to retain moisture significantly decreases, and it loses its ability to block out bacteria, viruses, pollutants, and allergens. This leads to dryness, dehydration, redness, sensitivity, itchiness, and even skin inflammatory issues such as eczema, psoriasis, and acne can become more prevalent!


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    | Accelerating Skin Aging by Breaking Down Collagen and Elastin Fibers


    Collagen and elastin fibers are essential elements for maintaining skin firmness, elasticity, and overall skin structure. However, chronic inflammation in the body can accelerate the breakdown and degradation of collagen and elastin fibers in the skin, leading to the appearance of wrinkles, fine lines, skin sagging, loss of elasticity and firmness, ultimately speeding up the overall skin aging process

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    | Impairing Skin Regeneration and Repair Ability


    The inflammatory process generates an excess of free radicals, increasing oxidative stress. This oxidative stress can exacerbate inflammatory issues, damage skin cells and DNA, affect wound healing processes, and impair skin regeneration and repair ability. This not only leads to premature skin dryness, dullness, loss of elasticity, wrinkles, sagging, and other signs of agin, but can also make problems like eczema, rosacea, psoriasis, sensitivity and redness, occur more frequently and severely.

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    | Hyperpigmentation and Uneven Skin Tone


    Melanin itself is a substance that protects the skin, but when there is an excess of melanin, it can lead to issues like hyperpigmentation, dullness, and uneven skin tone. Chronic inflammation in the body can cause chronic inflammation in the skin, and as part of the immune response, the skin would send signals to melanocytes to produce an excess of melanin in an attempt to protect the skin. When melanin accumulates and deposits over time, it results in visible hyperpigmentation, dullness, and uneven skin tone.

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    Chronic inflammation can manifest in various physiological and psychological ways. Identifying these signs and symptoms can help determine if your body is in a state of chronic inflammation:


    • Skin Issues
      Persistent acne, eczema, rosacea, psoriasis, or a sudden worsening or flare-up of these issues are signs of chronic body inflammation.

    • Persistent Fatigue
      Chronic body inflammation triggers the continuous release of pro-inflammatory factors, leading to persistent chronic fatigue and low energy levels.

    • Frequent Infections
      If you frequently or repeatedly experience bacterial and viral infections, or have difficulty recovering from infections, it may indicate an overactive immune response and the presence of chronic inflammation in the body.

    • Digestive Problems
      Chronic inflammation in the gut can lead to digestive issues such as bloating, diarrhea, or abdominal pain.

    • Joint Pain
      Chronic inflammation in the body can cause joint pain and stiffness, which are also primary symptoms of arthritis.

    • Weight Gain
      Chronic body inflammation disrupts normal metabolic processes, leading to weight gain, especially in the abdominal region.

    • Emotional Disorders
      Chronic body inflammation is associated with mood disorders such as depression and anxiety. Feeling persistently sad, irritable, or anxious may be related to chronic inflammation in the body.

    • Chronic Pain
      Conditions like chronic headaches, fibromyalgia, or muscle pain may worsen due to chronic inflammation in the body.

    • High Blood Pressure
      Chronic inflammation can lead to endothelial dysfunction and arterial damage, resulting in high blood pressure.

    • Autoimmune Diseases
      Conditions like rheumatoid arthritis, lupus, or inflammatory bowel disease are associated with excessive immune responses, indicating underlying issues of chronic inflammation in the body.







    In daily diet, fish such as salmon, mackerel, sardines, herring, trout, and tuna, nuts and seeds like flaxseeds, chia seeds, and walnuts, as well as green tea, grapes, blueberries, turmeric, ginger, and onions, all help reduce inflammation in the body.

    Regarding supplements, the following nutrients also significantly help reduce chronic internal inflammation:


    |Spermidine


    • Spermidine can promote the process of cellular autophagy——this process not only helps in cell renewal and regeneration but also aids in destroying bacteria and viruses when the body is infected. Additionally, spermidine can strengthen the autophagy process to clear damaged proteins and organelles that turn into waste and cause inflammation, preventing them from attacking other cells and accelerating aging issues, while also reducing internal inflammation reactions.
    • Spermidine can inhibit the generation of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) to alleviate internal inflammatory responses.
    • Spermidine helps regulate the function of the immune system, while balancing the generation of pro-inflammatory and anti-inflammatory cytokines to reduce the occurrence of inflammation.
    • Spermidine possesses significant antioxidant properties, which helps to neutralize free radicals and reduce internal inflammatory responses caused by oxidative damage.
    • Spermidine can protect cells from damages and maintain normal cell function, thereby reducing inflammation issues.
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    |Taurine


    • Taurine can inhibit the overactivation of immune cells, balance immune responses, and regulate immune system function, thereby reducing the occurrence of chronic inflammation.
    • Taurine can suppress the generation of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) to alleviate internal inflammatory responses.
    • Taurine can promote the recovery of damaged tissues, and reduce tissue damage caused by inflammation.
    • Taurine contributes to the strengthening of cardiovascular health, thus helping to reduce inflammation reactions caused by heart health issues and cardiovascular diseases.
    • Taurine has antioxidant effects that helps to neutralize free radicals and reduce internal inflammatory responses caused by oxidative damage stress.




    |Omega-3 Fatty Acid


    • Omega-3 fatty acids can promote the generation of anti-inflammatory cytokines such as interleukin-10 (IL-10), while balancing the immune system and reducing inflammatory responses.
    • Pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) play a key role in the process of chronic inflammation in the body. Omega-3 fatty acids help reduce the generation of these pro-inflammatory cytokines, thereby alleviating internal inflammatory responses, which also have beneficial effects on skin inflammations like acne, psoriasis, eczema, and rosacea. In fact, studies have found that supplementing phospholipid-based omega-3 fatty acids from krill oil can reduce inflammatory and hormonal acne by up to 42%.
    • Omega-3 fatty acids can regulate the function of immune cells, preventing their overactivation and excessive responses, thereby reducing the occurrence of chronic inflammation.
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    • Omega-3 fatty acids help improve the structure and fluidity of cell membranes, while maintaining normal cell function and communication between cells. This indirectly improves and regulates inflammatory responses.
    • Omega-3 fatty acids help regulate lipid levels and reduce lipid accumulation, thereby reducing the chances of triggering inflammation in the body.
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    |MSM


    • MSM can balance the generation of pro-inflammatory and anti-inflammatory cytokines and regulate immune system function, thereby reducing the occurrence of chronic inflammation.
    • MSM helps maintain gut health, reduce intestinal inflammation, and promote intestinal immune function, thereby reducing overall internal inflammation issues.
    • MSM can alleviate arthritis and joint pain, while also reducing joint inflammation, leading to a decrease in internal inflammation.
    • MSM can inhibit the generation of pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), and thus can directly alleviate internal inflammatory responses, subsequently reducing skin inflammation issues like acne, eczema, rosacea, and psoriasis.
    • MSM can intercept free radicals, thereby reducing inflammatory responses caused by oxidative stress.
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    |Algae


    • Algae, with its range of anti-inflammatory substances such as chlorophyll and zinc, along with antimicrobial and detoxifying properties, can alleviate internal inflammation, improve conditions like redness, acne, eczema, psoriasis, and rosacea, and soothe itchiness, swelling, and sensitivity related to skin inflammation issues.
    • Oxidative stress leads to cell damage, which subsequently triggers internal inflammation. Algae are rich in various types of antioxidants, such as astaxanthin, beta-carotene, and amino acids like glycine and proline, all of which help combat free radicals, and reduce inflammation issues caused by cellular damage.
    • Algae can eliminate toxins and heavy metals that cause internal inflammation, thereby reducing inflammation occurrences.
    • Research confirms that there is a significant link between inflammation and high body acidity. Many foods like dairy, sugar, meat, grains, alcohol, salt, legumes, coffee, and even eggs can lead to increased body acidity. Additionally, factors like stress, toxins, environmental pollution, tobacco, inadequate sleep, and medications can also contribute to increased acidity in the body. Furthermore, our body generates acidic waste when using muscles, breathing, and digesting! Algae can help the body regain alkalinity and reduce inflammation.
    • Active compounds in algae have the ability to inhibit the generation of pro-inflammatory cytokines, and balance the ratio of pro-inflammatory and anti-inflammatory cytokines in the body, thereby reducing inflammatory responses.
    • The polysaccharides and protein components in algae aid in regulating immune system function, and reducing the risk of infections and inflammation.
    • Algae contain fiber and probiotics, which are beneficial for gut health, and can aid in reducing intestinal inflammation and improving nutrient absorption.
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    |Liver Support Supplements


    Taking liver support supplements can help alleviate chronic inflammation in tbe body because:


    • Our liver is the primary detoxification organ in our body. A healthy liver can metabolize and clear toxins efficiently, and minimize the damage harmful substances can cause in the body, thereby reducing the risk of chronic internal inflammation.
    • A healthy liver aids in clearing inflammatory mediators in the body, such as cytokines and metabolites, which helps to prevent overactivation of inflammatory responses.
    • Our liver can regulate immune responses, and a healthy liver further helps balance the generation of pro-inflammatory and anti-inflammatory cytokines, thereby reducing the occurrence of chronic inflammation.
    • The liver plays a crucial role in lipid metabolism, which helps to regulate blood lipid levels and fat breakdown. As fat accumulation decreases in body tissues, the risk of inflammation also decreases.
    • The liver can regulate blood sugar levels, helping to prevent inflammatory responses caused by blood sugar fluctuations.
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    |Parasite-Cleansing Supplements


    • Parasites are organisms that live inside other organisms, using them as hosts to obtain nutrients. When parasites reside within the human body, they interact with human tissues and organs, and release metabolites and toxins. This triggers the production of pro-inflammatory cytokines and other chemical substances in the body to attack and eliminate the parasites, leading to chronic internal inflammation. Parasite cleansing supplements can help remove parasites from the human body, thus reducing the risk of internal inflammation caused by them.
    • Parasites present in the human body produce metabolites and toxins that stimulate the immune system, leading to an immune response. When the immune response is overly activated, internal inflammatory reactions are significantly intensified, causing damage to body tissues and organs. Taking parasite cleanse supplements can prevent the activation of the immune response, thereby reducing the occurances of internal inflammation.
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    |Probiotics/span>


    • Microbiome imbalance in the gut can lead to a range of health issues, including chronic internal inflammation, as well as skin problems like acne, eczema, rosacea, and psoriasis. Probiotics can help maintain the balance of good bacteria and bad bacteria, while inhibiting the overgrowth of harmful bacteria, thereby reducing inflammation reactions in the gut, body, and skin.
    • Probiotics help enhance the function of the immune system, boost body resistance to external stimuli, and reduce the risk of infections and inflammation.
    • Some probiotics have antioxidant properties that can neutralize free radicals, thereby reducing inflammatory responses caused by oxidative damage.
    • Probiotics can regulate immune system responses, inhibit the overactivation of immune cells, and balance the generation of pro-inflammatory and anti-inflammatory cytokines, thereby reducing inflammation occurrences and decreasing skin sensitivity.
    • Probiotics can promote the repair and protection of the intestinal mucosa, and maintain gut health, thereby reducing the occurrence of gut and chronic internal inflammation.
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    |Collagen


    • The role of the outer wall of the human digestive system is to separate the body from other parts, and prevent toxins, harmful substances, food particles, and other materials from entering the bloodstream and other parts of the body. The issue is that these cell membranes are very thin; when we ingest food that the body does not accept or like, they may tear, rupture, and become damaged, causing gaps to appear. As a result, various substances from the digestive system would flow into other parts of the body. When these substances appear in places outside of the digestive system where they shouldn't be, the body identifies them as invaders, which can trigger an immune response that leads to chronic internal inflammation, and various types of skin inflammation problems such as acne, redness, eczema, rosacea, and dermatitis may occur. Collagen can repair damaged cells and reduce the gaps in the damaged intestinal mucosa. They also help strengthen the entire esophagus and increase cell elasticity, thus allowing the intestines to move more flexibly, and reduce damage caused by substance irritation. When the gut is healthy, the body is less likely to experience exaggerated inflammatory responses, which can significantly reducing the chances of chronic inflammation in the body.
    • Collagen is the key in building and maintaining connective tissues, joints, and cartilage throughout the body. Taking collagen helps repair damaged cells and increase cell elasticity, thereby reducing pain issues in these tissues and joints, as well as the risk of inflammation.
    • Collagen aids in wound healing and tissue repair, and can help speed up the recovery process of damaged tissues, thus reducing the chances of inflammation and infection.
    • Collagen possesses antioxidant properties that can neutralize free radicals, thus reducing inflammatory responses caused by oxidative damage.
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